Prior to returning home to the Bay State, he was a reporter at ABC affiliate WFTV, the top-rated station in Orlando, Florida. During the two years he spent reporting in Central Florida, he covered several national stories, including the Pulse nightclub shooting in Orlando, the deadly alligator attack at Disney World, President Obama's visit to Orlando, Hurricane Irma and Hurricane Matthew.

Before his time in the Sunshine State, he spent two years at WSPA, the CBS affiliate in Spartanburg, South Carolina. While in the Palmetto State, he spent a week in Columbia covering the Confederate flag controversy at the South Carolina State House. He also covered the devastating flooding in Richland County.

In 2015, he traveled to North Charleston to lead the station's coverage of the Walter Scott police shooting that made national headlines. He also exposed a legal loophole in South Carolina's concealed weapons permit law that forced officials to allow legally blind applicants to carry handguns. He also unearthed oversight problems at elder care facilities that cost taxpayers and put a strain on public safety resources.

Before heading to the Palmetto State, he spent two years at KRIS and KZTV, the NBC and CBS duopoly in Corpus Christi, Texas. During his time in the Lone Star State, he uncovered dozens of sex offenders living near elementary schools, investigated food stamp fraud and exposed a tanning salon that broke the law.

He also traveled to West, where he filed reports on the aftermath of the fertilizer plant explosion that garnered national attention.

In 2015, he was part of a team honored with a Southeast Emmy Award for best newscast.

In 2013, the Lone Star chapter of the National Academy of Television Arts and Sciences recognized him with an honorable mention in the reporter craft achievement competition.

Manzoni earned a bachelor's degree in broadcast journalism and political science from Hofstra University in Hempstead, New York.